Product Information. Imitrex nasal spray sumatriptan. Do you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40? Imitrex, AMERGE, and TREXIMET are registered trademarks of the GlaxoSmithKline group of companies. The other brands listed are trademarks of their respective owners and are not trademarks of GlaxoSmithKline. The makers of these brands are not affiliated with and do not endorse GlaxoSmithKline or its products. Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use IMITREX for a condition for which it was not prescribed. Do not give IMITREX to other people, even if they have the same symptoms you have. It may harm them.
IMITREX are not presently available. You may have to try different drugs or doses. If you have already tried several medicines, your doctor may order tests such as an or to find out if a health problem is causing your headaches. Food and Drug Administration.
Our Imitrex Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. USP in water for injection, USP. To prevent upset, take this medication with food, milk, or an antacid. Do not break, crush, or chew the tablet. Before you use any treatment for a memory problem, discuss the potential risks and benefits of the treatment with your doctor. Tmax was 12 minutes after injection range: 5 to 20 minutes.
These medicines can help prevent headaches even if you don't have or seizures. Includes patients that may have received an additional placebo injection 1 hour after the initial injection. d Includes patients that may have received an additional 6 mg of Imitrex Injection 1 hour after the initial injection. If any of these effects persist or worsen, notify your doctor or promptly.
Gastrointestinal: Ischemic colitis with rectal bleeding see xerostomia. If the answer to any of the following questions is YES or if you do not know the answer, then please discuss with your doctor before you use IMITREX Injection. There are many reasons why people have trouble taking their medicine. After each use the Pen must be put back into the Carrying Case to reset the white Priming Rod before the next use. If your symptoms are only partly relieved or your headache returns, 2 hours after the injection you may switch to sumatriptan taken by mouth instead of using a second injection. After the initial injection you may take sumatriptan by mouth every 2 hours if needed to a maximum of 100 milligrams of tablets in a 24-hour period. Overuse of drugs to treat sudden attacks can lead to worsening of medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. An autoinjector device IMITREX STATdose Pen is available for use with 4-mg and 6-mg prefilled syringe cartridges. Postmarketing Experience Reports for Subcutaneous or Oral Sumatriptan: The following section enumerates potentially important adverse events that have occurred in clinical practice and that have been reported spontaneously to various surveillance systems. The events enumerated represent reports arising from both domestic and nondomestic use of oral or subcutaneous dosage forms of sumatriptan. The events enumerated include all except those already listed in the ADVERSE REACTIONS section above or those too general to be informative. Because the reports cite events reported spontaneously from worldwide postmarketing experience, frequency of events and the role of IMITREX Injection in their causation cannot be reliably determined. It is assumed, however, that systemic reactions following sumatriptan use are likely to be similar regardless of route of administration.
Take one sumatriptan tablet whole with a full glass of water. Do not split the tablet. The most successful ways to treat the pain are a shot of and breathing oxygen through a face mask for 20 minutes. Other drugs used for migraines called triptans may work. Prescription medicines based on the ergot and nasal spray might also help. Close the Carrying Case lid. They are especially helpful if you have moderate to severe that interfere with your ability to perform daily tasks. IMITREX. Such reactions can be life threatening or fatal. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. Imitrex Injection is contraindicated in patients with a history of hypersensitivity reaction to IMITREX. IMITREX Injection, 0% placebo. Injection is indicated in adults for 1 the acute treatment of migraine, with or without aura, and 2 the acute treatment of cluster headache. If you suffer with headaches that over the counter doesn't help with, ask for this or other migraine medicine. The sum of the percentages cited is greater than 100% because patients may experience more than 1 type of adverse event. Only events that occurred at a frequency of 1% or more in groups treated with IMITREX Injection and were at least as frequent in the placebo groups are included. Some people who use too many Imitrex tablets may have worse headaches medication overuse headache. If your headaches get worse, your healthcare provider may decide to stop your treatment with Imitrex. IMITREX can cause dizziness, weakness, or drowsiness. Five controlled clinical trials 2 single-attack trials, 3 multiple-attack trials evaluating oral IMITREX 25 to 100 mg in pediatric patients 12 to 17 years of age enrolled a total of 701 pediatric migraineurs. These trials did not establish the efficacy of oral IMITREX compared with placebo in the treatment of migraine in pediatric patients. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse reactions in these patients appeared to be both dose- and age-dependent, with younger patients reporting reactions more commonly than older pediatric patients. imitrex
Priming Rod does not stick out and to get the Pen ready for the next use. Imitrex Nasal Spray is indicated for the acute treatment of attacks with or without in adults. Metabolism: In vitro studies with human microsomes suggest that sumatriptan is metabolized by MAO, predominantly the A isoenzyme. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid IAA or the IAA glucuronide, both of which are inactive. IMITREX STAT dose Pen. Table 2 shows the 1- and 2-hour efficacy results. Remove device cover; remove disposable nosepiece from foil pouch and insert into the device until a click is heard; fully press and release white button to pierce capsule. Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions, including: high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, smoker, postmenopausal women age more than 40 years men. The incidence of adverse events in controlled clinical trials was not affected by gender or age of the patients. There were insufficient data to assess the impact of race on the incidence of adverse events. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. TIA. Discontinue Imitrex Tablets if a cerebrovascular event occurs. Hepatic Impairment: The liver plays an important role in the presystemic clearance of orally administered sumatriptan. Accordingly, the bioavailability of sumatriptan following oral administration may be markedly increased in patients with liver disease. The dosage is based on your medical condition, age, and response to treatment. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your comes back, you may take another dose at least two hours after the first dose. Do not take more than 2 doses in a 24-hour period. Storage requirements: The manufacturer's product information should be consulted. Inform patients that Imitrex Injection may cause serious cardiovascular side effects such as myocardial infarction or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, irregular heartbeat, significant rise in blood pressure, weakness, and slurring of speech, and should ask for medical advice if any indicative sign or symptoms are observed. ohnu.info nolpaza
You can take it as a nasal spray or shot. Pregnant women should not take DHE because it can cause birth defects. She prescribed Compazine Prochlorperazine. Overuse of Imitrex spray can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor. USP in Water for Injection, USP. The frequency and time to use of these additional treatments were also determined. Single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. Burns and scars have been reported on the skin where the transdermal iontophoretic transdermal system has been worn. These reports describe severe redness, pain, skin discoloration, blistering, and cracked skin. On June 13, 2016, the manufacturer of the patch suspended sales and distribution of the patch to investigate the cause of these reports. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Injection in pregnant women. Mild or flushing may occur. These effects are usually temporary and may disappear as your body adjusts to this product. If any of these effects persist or worsen, contact your doctor or promptly. Defects in the corneal epithelium were noted in a 60-week study. Earlier examinations for these toxicities were not conducted and no-effect doses were not established; however, the relative plasma exposure at the lowest dose tested was approximately 3 times the human exposure after a 6-mg subcutaneous dose. For subcutaneous injection only. Your healthcare provider may change your dose. Do not change your dose without first talking to your healthcare provider. You should give an injection as soon as the symptoms of your headache start, but it may be given at any time during a migraine or cluster headache attack. NDC 0173-0478-00 IMITREX Injection cartridge pack containing 2 prefilled syringe cartridges for refill of IMITREX STATdose System only. HT1 agonists have not been clearly established.
Imitrex is not used to treat other types of headaches such as hemiplegic that make you unable to move on one side of your body or basilar rare form of migraine with aura migraines. Consult your doctor before -feeding. IMITREX sumatriptan succinate Injection is a selective 5-hydroxytryptamine 1 receptor subtype agonist. How should I store Imitrex Injection? Table 3, onset of relief began as early as 10 minutes following a 6-mg Imitrex Injection. Lower doses of Imitrex Injection may also prove effective, although the proportion of patients obtaining adequate relief was decreased and the latency to that relief is greater with lower doses. Imitrex Injection is not indicated for the prevention of migraine or cluster headache attacks. Inform patients that the injection is intended to be given subcutaneously and intramuscular or intravascular delivery should be avoided. Instruct patients to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. Living with a family member who has a decline in memory, problem-solving ability, learning ability, or judgment is hard. Concomitant Drug Use: In patients taking MAO-A inhibitors, sumatriptan plasma levels attained after treatment with recommended doses are nearly double those obtained under other conditions. Accordingly, the coadministration of sumatriptan and an MAO-A inhibitor is not generally recommended. There may be new information. There was no evidence to suggest that treatment with Imitrex Tablets was associated with an increase in the severity of recurrent headaches. Some sumatriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients treated with 5-HT 1 agonists, including patients without a history of hypertension. Monitor blood pressure in patients treated with IMITREX. Imitrex Injection is contraindicated in patients with uncontrolled hypertension. Focus your attention. Often forgetfulness may mean that you have too much on your mind. Slow down and pay full attention to the task you are doing now. Take this medication by mouth with or without food as directed by your doctor, at the first sign of a migraine. The dosage is based on your medical condition and response to treatment. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may take another dose at least two hours after the first dose. Do not take more than 200 milligrams in a 24-hour period. quetiapine
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Vagus nerve, since the headaches are immediately connected to the urge to have a bowel movement. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Migraines: One type of drug, called triptans, is the mainstay of migraine treatment. They include eletriptan Relpax naratriptan Amerge rizatriptan Maxalt sumatriptan Imitrex, Zecuity zolmitriptan Zomig and others. Store at room temperature away from moisture, heat, and light. Throw away any unused medicine after the expiration date on the label has passed. What happens if I miss a dose? It is not known if Imitrex is safe and effective to treat cluster headaches. Best of luck to you. This is a very scarey and painful problem. Imitrex Nasal Spray sumatriptan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Check the expiration date on the Cartridge Pack. IMITREX. Such reactions can be life threatening or fatal. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction. Do not take any MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. If your migraine symptoms go away and then come back, you may use a second dose as directed by your doctor. Wait at least 2 hours between doses. generic varenicline discussion
Keep all regular medical and laboratory appointments. An extra patient leaflet is available with Imitrex spray. Talk to your pharmacist if you have questions about this information. Cluster Headache: The efficacy of IMITREX Injection in the acute treatment of cluster headache was demonstrated in 2 randomized, double-blind, placebo-controlled, 2-period crossover trials. Patients age 21 to 65 were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Headache relief was defined as a reduction in headache severity to mild or no pain. In both trials, the proportion of individuals gaining relief at 10 or 15 minutes was significantly greater among patients receiving 6 mg of IMITREX Injection compared to those who received placebo see Table 3. One study evaluated a 12-mg dose; there was no statistically significant difference in outcome between patients randomized to the 6- and 12-mg doses. Five controlled clinical trials 2 single attack studies, 3 multiple attack studies evaluating oral sumatriptan 25 to 100 mg in pediatric patients aged 12 to 17 years enrolled a total of 701 adolescent migraineurs. These studies did not establish the efficacy of oral sumatriptan compated to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse events in these patients appeared to be both dose- and age-dependent, with younger patients reporting events more commonly than older adolescents. Do you have any symptoms before the headache starts? Treatment with Imitrex Injection may cause somnolence and dizziness; instruct patients to evaluate their ability to perform complex tasks after administration of Imitrex Injection. Cardiovascular: Abdominal aortic aneurysm, angina, atherosclerosis, cerebral ischemia, cerebrovascular lesion, heart block, peripheral cyanosis, phlebitis, thrombosis, and transient myocardial ischemia. And if you are like me, Never eat chocolate before bed! This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Some of the side effects that can occur with sumatriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Pen firmly against your skin to give a dose. Swelling in the feet, lower legs, or fingers. If you do not get relief from the first dose of this medicine, do not take a second dose without first talking to your healthcare provider.
IAA or the IAA glucuronide, both of which are inactive. AUC corresponding to a 40% increase in elimination half-life. No significant effect was seen with an MAO-B inhibitor. Oral sumatriptan has not been evaluated for race differences. Choose and Prepare the Injection Site. You should not use sumatriptan if you have any history of heart disease or coronary artery disease, blood circulation problems, Wolff-Parkinson-White syndrome, uncontrolled high blood pressure, severe liver disease, circulation problems affecting your intestines, history of a stroke, or if your headache seems to be different from your usual migraine headaches. carbimazole buy online store australia
The studies did not establish the efficacy of sumatriptan nasal spray compared to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. General: Chest, jaw, or neck tightness is relatively common after administration of IMITREX Injection. Chest discomfort and jaw or neck tightness have been reported following use of IMITREX Tablets and have also been reported infrequently following the administration of IMITREX sumatriptan Nasal Spray. Only rarely have these symptoms been associated with ischemic ECG changes. However, because sumatriptan may cause coronary artery vasospasm, patients who experience signs or symptoms suggestive of angina following sumatriptan should be evaluated for the presence of CAD or a predisposition to Prinzmetal variant angina before receiving additional doses of sumatriptan and should be monitored electrocardiographically if dosing is resumed and similar symptoms recur. Higher doses may have a greater effect, but also carry a greater risk of adverse reactions. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Imitrex Injection. It is unknown if Imitrex Injection will harm a fetus. Your name may need to be listed on a sumatriptan pregnancy registry when you start using Imitrex Injection. Imitrex Injection can pass into breast milk and may harm a nursing baby. Do not breastfeed within 12 hours after using Imitrex Injection. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Imitrex. See the end of this leaflet for a complete list of ingredients in Imitrex. IMITREX in patients with migraine. This drug should not be used for prophylaxis. The nerve that's affected, the trigeminal nerve, is responsible for sensations such as heat or pain in your face. Keep IMITREX and all medicines out of the reach of children. IMITREX Injection is administered to treat any subsequent attacks. For women, at what time in your monthly cycle do they happen? Selective serotonin reuptake inhibitors SSRIs eg, fluoxetine serotonin-norepinephrine reuptake inhibitors SNRIs eg, duloxetine or sibutramine because the risk of a serious side effect called serotonin syndrome may be increased. buy triamcinolone online canada
Anti-nausea medications. These drugs may help you absorb your pain medication. Initial dose: 6 mg subcutaneously, once. If symptoms recur, the dose may be repeated if at least 1 hour has elapsed since the first dose. The onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medication. Discontinue Imitrex Injection if serotonin syndrome is suspected. HT1 agonists. Discontinue IMITREX Injection if these disturbances occur. What is the most important information I should know about IMITREX? Chiropractic and osteopathy. When causes tension headaches, a may be able to ease it with spinal or cervical manipulation and realignment. After taking a sumatriptan tablet, you must wait two 2 hours before taking a second tablet. Do not take more than 200 mg of sumatriptan tablets in 24 hours. Imitrex tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex tablets with caution. Plot also includes patients who had no response to the initial dose. IMITREX Injection is contraindicated in patients with hypersensitivity to sumatriptan or any of its components. They may have fewer side effects than prescription drugs. Do not press the Blue Button yet. Is this headache different from your usual migraine attacks?
The risk of heart disease, liver disease, and high blood pressure increases with age. The manufacturer does not recommend the use of sumatriptan in the elderly since they may be more sensitive to the side effects, including an increase in blood pressure. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. IMITREX Injection is intended to relieve your migraine or cluster headache, but not to prevent or reduce the number of attacks you experience. Use IMITREX Injection only to treat an actual migraine or cluster headache attack. Pen from accidentally firing until you are ready. Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex spray. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. The goal: Choose what works, use it first, and use it fast. What should I avoid while taking Imitrex? What are the possible side effects of IMITREX? prazosin order now pharmacy europe
Prinzmetal variant all forms of myocardial infarction, and silent myocardial ischemia. Cerebrovascular syndromes include, but are not limited to, strokes of any type as well as transient ischemic attacks. Do not use sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. These trials did not establish the efficacy of oral Imitrex compared with placebo in the treatment of migraine in adolescents. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. IMITREX Injection is contraindicated in patients with severe hepatic impairment. The maximum single recommended adult dose of IMITREX Injection is 6 mg injected subcutaneously. Controlled clinical trials have failed to show that clear benefit is associated with the administration of a second 6-mg dose in patients who have failed to respond to a first injection. Before you use IMITREX STATdose System your healthcare provider should show you or your caregiver how to give an injection the right way. It helps to keep a daily diary about your headaches. Every day, simply note whether you got one, and if you did, what symptoms you had. It also helps to include information about what you had to eat or drink, what was going on that day in your life, and how you slept the night before. Avoid for at least 12 hours after using sumatriptan. Consult your doctor before -feeding. Have you had, or do you have, any disease of the liver or kidney? Follow all directions on the product package. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 sumatriptan-treated headaches. Treatment for these health problems also may help you have fewer headaches. Take the Pen out of the Carrying Case. proventil
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The opinions expressed in WebMD Communities are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. Communities are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Side effects may go away after you take the medicine for a while. For patients with risk factors predictive of CAD who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of sumatriptan injection take place in the setting of a physician's office or similar medically staffed and equipped facility. Because cardiac ischemia can occur in the absence of clinical symptoms, consideration should be given to obtaining on the first occasion of use an electrocardiogram ECG during the interval immediately following IMITREX Injection, in these patients with risk factors.
Do not use more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor. Imitrex. These reports include reactions similar in nature to those reported rarely in adults, including stroke, visual loss, and death. The safety of treating an average of more than 4 headaches in a 30-day period has not been established. This is truly the worst pain I have ever experienced, and I'm no stranger to pain. It is sharp, burning and frightening. And it happens immediately when I start to have a bowel movement, so I know for certain they are related. I just can't find any medical information about this, besides some other folks on message boards who seem to be experiencing the same symptoms.
Are you using inadequate contraception? What should I tell my healthcare provider before taking Imitrex? Overuse of drugs to treat sudden migraine attacks can lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches.
Musculoskeletal: Infrequent were various joint disturbances pain, stiffness, swelling, ache. Rare were muscle stiffness, need to flex calf muscles, backache, muscle tiredness, and swelling of the extremities. TIA. Discontinue Imitrex Injection if a cerebrovascular event occurs. HGPRT assay. In 2 cytogenetics assays the in vitro human lymphocyte assay and the in vivo rat micronucleus assay sumatriptan was not associated with clastogenic activity. Respiratory: Asthma, breathing disorders, bronchitis, cough, and lower respiratory tract infection. If not, I eat something and take the rest of the pill about an hour later.